Metrozine is, used as an antidote to trichomoniasis, a bacterial disease caused by trichomonas. The drug may also be useful for the treatment of balantidiasis. However, should use with caution. Metrozine can cause adverse reactions in patients, including headaches, nausea, and vomiting. In some cases, the drug may cause flushing and abdominal cramps.
Indicated for the treatment of trichomoniasis
Infections caused by trichomoniasis, also known as trich, can be curable with an antibiotic. Treatment typically involves one dose of several tablets a day for a week. Most patients cure within this time frame. Treatment also includes frequent testing to make sure you are, not infected again. Since trichomoniasis can transmit to other people, it is important to use condoms and avoid intercourse with a new partner while you are taking antibiotics.
Most cases of trichomoniasis have few or no symptoms. Infections can last for months or even years if left untreated. Symptoms of infection may include pain in the vagina, malodorous discharge, and dyspareunia. In women, trichomoniasis can lead to a range of complications including vaginitis, epididymitis, and even infertility.
Treatment of trichomoniasis has many benefits, including reduced risk of HIV transmission and STIs. Besides relieving symptoms, treatment of trichomoniasis also helps improve patient compliance. Newer treatments, such as oral 2-g SEC, provide an option to treat both trichomoniasis and BV in one single dose. The oral 2-g SEC is, an FDA-approved antibiotic and is, expected to improve patient compliance.
Metrozine is an antimicrobial, used for the treatment of trichomonias infection. This drug is highly effective against T. vaginalis, but has many side effects including mucosal ulceration.
It can cause disulfiram-like reaction to alcohol
Patients on metronidazole should be aware that consuming alcohol while on this drug may lead to a disulfiram-like reaction. However, this reaction is uncommon. It is most likely, caused by the drug’s ability to inhibit aldehyde dehydrogenase, which can continue for up to 3 days after treatment has ceased.
Disulfiram, also known as tetraethylthiuram disulfide, is a chemical used to accelerate the production of rubber. In the 1800s, a Connecticut chemical plant physician noticed the drug’s reaction to alcohol when workers were grinding rubber. Workers who consumed disulfide showed symptoms of flushing, rapid pulse, and palpitations. They also experienced a sensation of fullness in their eyes and faces.
Although disulfiram-like reactions to alcohol are highly individual, they can occur if two or more of the drugs mix together. In patients with liver problems, this reaction can result in a buildup of both drugs. Therefore, healthcare professionals should be aware of the possibility of this reaction and suggest alternative treatments. When metronidazole is administered to patients, a careful review of all medications should be performed to ensure that they do not contain any alcohol.
Metrozine can cause a disulfiram-like reaction to alcohol in some people, but the exact mechanism of how this occurs is unclear. The drug acts as an inhibitor of aldehyde dehydrogenase, a substance in the body that helps break down alcohol.
It can increase plasma concentrations of busulfan
A population pharmacokinetic model of busulfan in paediatric stem cell transplant patients was, designed to assess potential drug-drug interactions. The primary pathways of interest were glutathione conjugation and cytochrome P450 activity. Concomitant drugs were classified into CYP inhibitors, inducers and glutathione S-transferase depleters. The model was then qualified by bootstrap simulations.
Inhibitors of the enzyme CYP3A4 can increase the concentrations of busulfan in plasma. This could lead to severe toxicity and should be avoided by pregnant or breastfeeding women. Among the possible side effects of busulfan are sinusoidal obstruction syndrome, mucositis, and hepatic veno-occlusive disease. Metronidazole can also interfere with serum testing and cause falsely decreased values.
Busulfan is absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Its absolute bioavailability (AUC) is 80%+-20% for adults and 68%+31% for children. It has a terminal elimination half-life of 2.6 hours and is metabolized primarily by conjugation with glutathione. It undergoes extensive oxidative metabolism in the liver and forms at least 12 inactive metabolites.
Busulfan belongs to the class of alkylating agents. It is classified as a known carcinogen. When it binds to DNA, it creates guanine-adenine intrastrand crosslinks and inhibits DNA replication. This damage prevents cellular functioning and leads to the death of cells.
